A global health archive consisting of podoconiosis tissue slides and blocks (which was collected and imported into the UK before the introduction of the Human Tissue Act), was donated to Brighton & Sussex Medical School in 2014. There is little guidance on the socioethical and legal issues surrounding the retrospective use of archived or ‘abandoned’ tissue samples, which poses a number of questions relating to the ethical standing of the archive. There is a great deal of interpretation in the guidelines (...) that are currently in existence; however, modern ethical principles cannot be applied as it is not feasible to either reconsent or retrospectively seek approval. Our research team believed that it was unethical to leave the archive in storage, as this option favours neither researcher nor subjects. Permission was obtained from the Human Tissue Authority and a local ethics board for the tissues to be utilized in on-going research on podoconiosis aetiology. There is a delicate balance between the benefits gained by society relating to the development and progress of scientific research and the risks to the donor regarding the reuse of their tissues. Clearer guidelines should be made available to ensure that researchers are able to reuse tissue archives in contemporary research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Peculiarly Favored Condition of GeneticsJames J. Lee, PhD (bio) and Damien Morris, MSc (bio)Turkheimer and Greer (2024) (henceforth “T&G”) make some fair points about problems in the scientific profession, including the regrettable tendency to promise practical applications of research that then never materialize. However, T&G’s sustained critique of a body of work associated with one particular researcher to make these general points struck us as uncharitable. More (...) pressingly, we feel that the far-reaching conclusions that T&G attempt to draw from the results they review from the Spit for Science (S4S) cohort are unjustified and risk misleading readers that psychiatric and behavioral genetics is in a parlous state.T&G state that S4S “produced a clear answer to the question it was designed to address,” namely, that its results “unambiguously contradict the hypothesis that alcohol-related behaviors have a meaningful genetic basis.” But S4S cannot possibly have provided affirmative evidence for the null hypothesis, because as a single cohort it lacked the statistical power to do so. Elsewhere T&G acknowledge that the sample size of S4S does not suffice for many purposes; they cannot have it both ways. When GCTA has been applied to samples of greater size, it has unambiguously supported the hypothesis that alcohol-related behaviors have a meaningful genetic basis. The UK Biobank yielded estimates exceeding 0.10 for the contribution of single nucleotide polymorphisms (SNPs) with minor allele frequency of greater than 0.05 to the heritability of drinks per week, estimates more than ten times their standard errors (Liu et al., 2019).This heritability contributed by common variants is sometimes called “SNP heritability,” and T&G disparage it for the alleged “disadvantage of being substantially smaller” than “twin and family heritabilities.” Nowhere do T&G consider what the precise numbers actually mean—an approach that can be hazardous to your scientific health, as the late John Loehlin might have said. Let us, then, consider these numbers. Under a model of pure neutrality, SNP and pedigree narrow-sense heritabilities should be fairly close, essentially as a result of factors p(1 − p) canceling in the multiplication of the numbers of SNPs to be found at a given allele frequency by the average heritability contributed per SNP (Hill, 2010). If SNP and pedigree heritabilities are not close, then natural selection must have been acting on [End Page 441] the trait, preventing new mutations of large effect from becoming common and thereby concentrating heritability at allele frequencies lower than those typically studied in genome-wide association studies (GWAS). This deduction has been abundantly confirmed: the tendency of GWAS SNPs to reside in evolutionarily conserved regions (Finucane et al., 2015; Kim et al., 2019), the younger age of GWAS SNPs when compared to control SNPs of comparable frequencies (Gazal et al., 2017), the discovery of several rare variants with larger effects than those observed in typical GWAS (Barton et al., 2021; Chen et al., 2023; Marouli et al., 2017), the directly measured deleterious fitness effects of mutations in evolutionarily constrained genes (Gardner et al., 2022), and the substantial additional genetic variance accumulated when rare variants are included in GCTA-type studies, sometimes enough to close the gap between SNP and pedigree heritabilities (Evans et al., 2018; Jang et al., 2022; Pathan et al., 2024; Wainschtein et al., 2022).The genetic architecture of a typical quantitative trait consists of many sites across the genome that can mutate to affect it, numbering potentially in the millions (Agarwala et al., 2013; Zeng et al., 2021), of which those that are common SNPs have very small effects as a result of selection. This is the message, but T&G seem to find fault with the messenger, painting “tiny” effect sizes as an embarrassment to the field of behavioral genetics as a whole. We prefer to view the finding of high polygenicity as a revelation about nature, rather than as a debating point. What is this finding telling us? If one takes the action of stabilizing selection as the initial assumption (Uyeda et al., 2011), then the extreme polygenicity revealed by GWAS becomes part of the answer to the question regarding how traits can... (shrink)

ELSI efforts long have been troubled by critiques that they privilege scientific frameworks and grant scientists the power to set ethical agendas. As the first director of the Human Genome Project’...

This reference contains more than 600 cross-referenced dictionary entries on utopian thought and experimentation that span the centuries from ancient times to the present.

This Dictionary provides a wide range of coverage on a topic that has played a significant role in human society, from the early theoreticians and thinkers who proposed republican, democratic, and authoritarian innovations; to those who sought equality of classes, races, and genders; to those who insisted on hierarchy under a supreme leader, or god; and to those who had more practical economic, social, and ethical plans. This historical dictionary covers the most vital information on the persons, plans, and attempts (...) associated with utopianism that have been seen since ancient times. An introductory essay, chronology, 600 dictionary entries, an extensive bibliography, and an appendix listing the names and locations of utopian communities worldwide enable the reader to explore the Western mind's desire to improve the world and the lives of the people within it as utopianism has persisted over the centuries. (shrink)

The logical consistency of a collection of assertions about events can be viewed as a special case of coherent probability assessments in the sense of de Finetti.

Information is the reduction of uncertainty, and uncertainty is equivalent to entropy. Thus, information is negative entropy. Concepts from information theory can be used to analyse physiological and psychological processes and to probe the nature of abstract ideas such as consciousness and vitality. A previously published model of the Universe indicates that it consists of charge and entropy. Since entropy is energy, then charge and energy are enough to explain the whole of nature. The building blocks of molecules (neutrons, protons (...) and electrons) are formed of negative entropy. Complex high information systems (also negative entropy) lead to living organisms and eventually to complex multicellular organisms that are both vital and conscious. Most of the Universe is a void (maximum entropy) but there are tiny foci, such as the surface of the earth, which are information rich. Everything on the earth is composed of negative entropy—from the simplest physical structure to the most complex product of human thought. There is no fundamental difference between mind and matter. (shrink)

This is a selection of readings about professionalism and ethics in engineering. It addresses topics such as the concept of professionalism, education, and maintenance of competence, registration, professional autonomy, social effects and responsibilities, and enforcement of codes of ethics.

The purpose of this quantitative study of 401 students is to identify common motivations for Chinese students to plagiarize on written English assignments and ultimately to demystify and understand the mindset of Chinese students who do plagiarize. According to a regression analysis of these data, the most significant factor relating to likelihood to self-report plagiarism for Chinese students is the belief in a “standard answer,” which represents the correct answer to a given question. The regression results also suggest that students (...) who believe that imitation of experts is important to learning are more likely to self-report plagiarism, and that business students are more likely to self-report than non-business students. The other factors examined in our model, such as English writing ability; ability to express one’s self in English writing; embarrassment about English writing ability; concern for accuracy of English writing; and concerns about grade point average, were not significant predictors of self-reported plagiarism. These results give a key insight into the English writing plagiarism behaviors of Chinese students studying in Western higher education. (shrink)

The contemporary historical situation suggests fascinating parallels with that period of the 13th/7th century when the massive destruction of the Mongol invasions opened the way for popular new forms of Islamic life and practice that eventually spread Islam throughout Asia. Today, as in earlier periods of dramatic upheaval, we can witness those processes of inspiration and awakening that give rise to the spiritual pathways of future centuries, through each soul’s gradual discovery of its unique challenges and demands of ihsan. One (...) way of describing this transformation, to use the Qur’anic language adapted by Ibn ‘Arabi, is in the terms of the process of spiritual realization by which people discover their guiding inner relationship to those divine qualities or “Names” that eventually come to define the meaning and purpose of their lives. Through our life long movement of service to the “Lord” constituted by each divine Name, the transformation of the soul follows a familiar, naturally ascending trajectory. It begins with a curiosity drawing us toward some particular dimension of the Real ; then a compelling striving leading to heightened discipline and awareness; and ultimately to the creative manifestation of that devotion through the appropriate means of teaching, communication, and new communities of fellow- seekers—the Qur’anic “servants of the All-Merciful”—that slowly emerge from this shared spiritual work of devotion, discovery and creative response. Here we point to some ways this process of civilizational renewal is unfolding around the world, focusing on three of the most far-reaching of those divine Names: the “servants of the All-Wise”, in their exploring and deciphering the infinite Signs of God’s Wisdom “on the horizons”, in all of the sciences of nature and society; to those muhsinūn and “servants of the Beautiful” whose creative acts of beauty help awaken that love and awe which mark the beginnings of each spiritual journey; or to those “servants of the Subtly-Gracious” whose lives are dedicated to deepening our understanding of the presence and meaning of each of the divine Signs “in our souls,” in the emerging science of spirituality. These “servants of the all- Merciful” and their communities are themselves the first seeds of an emerging global civilization. (shrink)

The Metaphysical Club, a gathering of intellectuals in the 1870s associated with Harvard, is widely recognized as the crucible where pragmatism, America's distinctively original philosophy, was refined and proclaimed. Louis Menand's bestseller about the group was a dramatic publishing success. However, only three actual members - Oliver Wendell Holmes Jr., Charles S. Peirce, and William James - appear in this book, alongside other thinkers such as John Dewey who were never in the Club. The Real Metaphysical Club tells the (...) full story of how this influential group shifted the course of philosophy in America. In addition to pioneering pragmatism, the group explored radical empiricism and idealism, and formulated personalism and process philosophy, equally important developments. This volume contains thirty-seven important writings dating from 1870 to 1885 by the real members of the Metaphysical Club. The first section centers on pragmatism and science; the second part collects writings of the lawyers; and the third part covers idealist and personalist philosophers. Many of these writings have never been reprinted before, and nothing like this impressive collection has ever been attempted. A general introduction provides a narrative history, and the editors' three introductions to the volume's sections vividly bring to life the intense meetings, sustained debates, and pioneering thought from the Metaphysical Club. (shrink)

"A meticulous, well-tuned examination of what Janowitz says is the decline of civic thought in America, and what might be done to restore it.... The patriotism Janowitz proposes to reconstruct is not the sort of narrow nationalism your political science professor may have warned you about—patriotism as 'the last refuge of a scoundrel.' It is instead a patriotism that intelligently appreciates life in a democratic land."—Robert Marquand, _The Christian Science Monitor_ "In _The Reconstruction of Patriotism,_ Morris Janowitz... places a (...) national-service program on the national agenda.... Like William James, Janowitz envisions government enrolling young people to work for a year or two at subsistence pay, doing jobs that benefit society—working with, say, 'conservation, health, or old-age problems.' He believes that we need a service program because since the end of the Second World War our citizens have become more keenly aware of their rights than of their obligations, and generations are growing up with little or no understanding that they are members of a national community and have responsibilities to it—that they must give as well as take.... Because it reopens discussion of our wider obligations and how to fulfill them, Mr. Janowitz's thoughtful book is in itself a national service."—Naomi Bliven, _The New Yorker_ "Morris Janowitz examines an issue that seldom is subject to social and political analysis—patriotism. His thesis is clear: The long-term trend in politics has been to enhance citizen rights without effective articulation of citizen obligations. A meaningful balance between the two, he contends, must be restored.... The strength of this study lies in Janowitz's persuasive argument that the durability and vitality of democratic institutions require that a sense of community, or shared values, be preserved. Without civiz consciousness, he rightly observes, social and political fragmentation ensues.... A lucid and impressively researched polemic."—W. Wesley McDonald, _American Political Science Review_ "Janowitz addresses a seminal issue: how to restore the sense of shared civic responsibility that has fallen victim in recent years to our growing preoccupation with individual rights and the rise of special-interest groups.... Central to his prescription is the revival of the concept of the citizen soldier, whose importance since pre-Revolutionary War days Janoqitz discusses at length. He concludes, 'There can be no reconstruction of patriotism without a system of national service.'... An important book. I highly recommend it."—_Washington Monthly_. (shrink)

Sex chromosomes are advantageous to mammals, allowing them to adopt a genetic rather than environmental sex determination system. However, sex chromosome evolution also carries a burden, because it results in an imbalance in gene dosage between females (XX) and males (XY). This imbalance is resolved by X dosage compensation, which comprises both X chromosome inactivation and X chromosome upregulation. X dosage compensation has been well characterized in the soma, but not in the germ line. Germ cells face a special challenge, (...) because genome wide reprogramming erases epigenetic marks responsible for maintaining the X dosage compensated state. Here we explain how evolution has influenced the gene content and germ line specialization of the mammalian sex chromosomes. We discuss new research uncovering unusual X dosage compensation states in germ cells, which we postulate influence sexual dimorphisms in germ line development and cause infertility in individuals with sex chromosome aneuploidy. (shrink)

Conventional theory assumes that economic agents perform at optimal levels of efficiency by definition and this is achieved when individuals behave in a particular fashion. Moreover, neoclassical production theory masks the process by which optimal output can be achieved. I argue that economic theory should be revised to incorporate some key findings of behavioural economics, while retaining the conventional theory’s normative ideal of optimum output whilst rejecting its normative procedural ideals of how to achieve optimality in production. I argue that (...) neoclassical procedures can be expected to yield sub-optimal levels of output and therefore should not be benchmarks for procedural rationality. I present an alternative more realistic and analytically precise specification of the production function related to the fast and frugal heuristics narrative pioneered by Gigerenzer and Leibenstein’s x-efficient theory. This approach incorporates an understanding of the appropriate procedures, psychological and organization variables, decision-making capabilities and end-goals required to achieve optimality in production and, thereby, grow the wealth of nations, thereby enhancing the material wellbeing of the population at large. This also provides us with the tools to better identify economic inefficiency and the conditions that contribute to it. (shrink)

The rise of experimental philosophy has placed metaphilosophical questions, particularly those concerning concepts, at the center of philosophical attention. X-phi offers empirically rigorous methods for identifying conceptual content, but what exactly it contributes towards evaluating conceptual content remains unclear. We show how x-phi complements Rudolf Carnap’s underappreciated methodology for concept determination, explication. This clarifies and extends x-phi’s positive philosophical import, and also exhibits explication’s broad appeal. But there is a potential problem: Carnap’s account of explication was limited to empirical and (...) logical concepts, but many concepts of interest to philosophers are essentially normative. With formal epistemology as a case study, we show how x-phi assisted explication can apply to normative domains. (shrink)

Amidst the “lavender scare” of the Cold War, James Schuyler, “the great queer voice of the New York School,” subverted the state’s auditory surveillance of queer life. Refunctionalizing its tools of espionage as poetic tactics, Schuyler eavesdrops on errant conversations (the espoused) and joining (espousing) them in paratactic assembly. In so doing, Schuyler expands José Esteban Muñoz’s “queer optic,” the utopian capacity to see beauty amidst ruins, beyond the visual into a queer otic that drags into being a world (...) of freer espousal. I survey the aural surveillance of mid-century queer life before tracing Schuyler’s détournement of bugging, wiretapping, and overhearing in his 1969 Freely Espousing. In turn, I uncover the queer political commitments lurking beneath Schuyler’s classification as a pastoral lyricist concerned only with “leaves and flowers and weather.”. (shrink)